小儿支气管哮喘与肺炎支原体感染关系的临床研究

Clinical Study on Relationship between Bronchial Asthma in Children and Infection with Mycoplasma Pneumonia

目的探讨小儿支气管哮喘与肺炎支原体(MP)感染的关系。方法儿童哮喘专科门诊及住院哮喘发作期患儿193例(哮喘组)及同期就诊的呼吸道感染患儿213例(对照组),采用MP被动冷凝集法检测血清肺炎支原体抗体(MP-Ab)。结果哮喘组MP-Ab阳性93例,阳性率48.2%;对照组阳性53例,阳性率25.8%,两组比较差异显著(P<0.01)。结论MP感染与儿童哮喘关系密切,MP导致呼吸道慢性炎症,进而改变呼吸道高反应性是最根本的机制。对哮喘发作期的患儿要考虑MP感染可能,应常规行MP-Ab检查。

Objective To discuss the relationship between bronchial asthma in children and mycoplasma pneumonia（MP） infection. Method All the 193 cases of paroxysmal asthma（bronchial asthma group） from our hospital were selected. 213 children with respiratory tract infection served as control group. MP-Ab was detected by CAT method in both groups. Results MP-Ab was positive in 93 cases（48.2% ） in bronchial asthma group ;53 cases（25.8% ） in control group. There was a significant difference between the two groups（P 〈 0. 01 ）. Conclusions There is a close relationship between MP infection and children bronchial asthma. The essential mechanism is that MP leads to chronic inflammation of respiratory tract, which changes the hyper reac- tivity of respiratory tract. The possibility of MP infection should be taken into account while treating children wtih paroxysmal asthma. MP-Ab should be detected routinely in children with paroxysmal asthma.