肠道树突状细胞在多器官功能障碍综合征中的作用

Study on the role of intestinal dendritic cells in multiple organs dysfunction syndrome

【目的】探讨小肠树突状细胞（DCs）在多器官功能障碍综合征（MODS）外周免疫器官损伤中的病理过程和作用机制。【方法】复制小鼠MODS动物模型，采用光镜、电镜、免疫组化（CD11c，I-Ab）等方法观察小肠病理学及其DCs在MODS病程中的动态变化。【结果】实验早期（3～6h），DCs显著增生且功能活跃；晚期（10～12d）大量DCs失活。【结论】小肠DCs数量和活性的变化在MODS小鼠外周免疫应答和维持机体免疫平衡过程中具有重要作用。

[Objective] To explore the pathological features of the interstitial dendritic cells （DCs） in the small intestine and their role in the pathogenesis in multiple organ dysfunction syndrome （MODS） . [Methods] The MODS model of mice was repro- duced. The changes in DCs in the small intestine in mice with MODS were studied using ligh microscope, electronic microscope, immunohistochemistry （I-Ab, CDllc, IL-1β, IL-10） . [Results] Conclusion During the course of MODS, changes inResults In the early stage （3 - 6 h）, there was hyperplasia with increased activity of DCs in the small intestine. In the MODS stage （ 10 - 12 d）, the number of DCs increased. [Conclusions] the number and activity of DCs in small intestine are very important in the Establishment of immune response and maintenance of immune function.