摘要
采用放射配体结合实验，研究大鼠对烟碱形成依赖后脑皮层Ｍ、Ｎ胆碱能受体的变化，结果显示，形成烟碱依赖后脑皮层Ｍ－受体的亲和力与密度均无改变；Ｎ－受体亲和力也无明显变化，而Ｎ－受体密度则从对照组的９０ｆｍｏｌ·ｍｇ－１±ｓ５ｆｍｏｌ·ｍｇ－１蛋白上调到１３１ｆｍｏｌ·ｍｇ－１±ｓ９ｆｍｏｌ·ｍｇ－１蛋白。表明烟碱依赖与脑Ｎ－受体上调相关。
The effects of nicotine dependence in M and N cholinergic receptors(M-and N-R) in rat brains were studied by radioligand-receptor binding assay.The results showed that after developing nicotine dependence (1) the affinity and density of M-R in the brains unchanged; (2) the density of N-R in the brains was significantly upregulated from 91 fmol·mg-1±s 5 fmol·mg-1 protein in control group to 131 fmol·mg-1±s 9 fmol·mg-1 protein in nicotine-dependent group,while there was no change in the affinity.These indicated that nicotine dependence might be related to upregulation of N-R in rat brains.
出处
《中国药物依赖性杂志》
CAS
CSCD
1998年第2期81-84,共4页
Chinese Journal of Drug Dependence
关键词
烟碱
药物依赖性
受体
胆碱能
脑
nicotine
drug dependence
receptor
cholinergic
brain
