期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

丙酮酸激酶M2型在肿瘤发生过程中的作用 被引量：2

Functions of pyruvate ldnase M2 in tumorigenesis
原文传递
导出
摘要 人丙酮酸激酶（PK）有M1、M2、R和L等4种同工酶。其中M2型主要在早期胚胎组织中表达，胎儿出生后逐渐被其他3种同工酶取代，但在成体干细胞中人丙酮酸激酶也有表达。几乎所有的肿瘤细胞都存在M2型表达，并同各种内源性、外源性癌蛋白及增殖调节因子相互作用以增强肿瘤细胞的增殖，因此被称为肿瘤特异性丙酮酸激酶。 Human pyruvate kinase （hPK） has four isozymes-M1 ,M2, R and L,among which M2 gene is mainly expressed in early embryonic tissues and its expression is progressively replaced by the other three isozymes after birth. But expression of hPKM2 gene remains in adult stem cells. In addition, it is specifically present in most tumor cells, hPKM2 seems to interact with different kinds of endogenous, exogenous oncoproteins and factors that regulate cell growth to enhance proliferation of tumor cells. Thus, hPKM2 has been named as tumor specific PK.
作者 胡修明(综述) 蒋纪恺(审校)
机构地区 汕头大学医学院生物化学与分子生物学教研室
出处 《国际肿瘤学杂志》 CAS 2009年第5期348-351,共4页 Journal of International Oncology
关键词 丙酮酸激酶 糖酵解 癌基因蛋白质 标记物 Pyruvate kinase Glycolysis Oncogene proteins Marker
分类号 R446.112 [医药卫生—诊断学] R273 [医药卫生—中西医结合]
  • 相关文献

参考文献19

  • 1Dombrauckas JD, Santarsiero BD, Mesecar AD. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry, 2005, 44(27) :9417-9429.
  • 2Mazurek S, Boschek CB, Hugo F, et al. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol, 2005, 15(4) :300-308.
  • 3Wu X, Zhou Y, Zhang K, et al. Isoform-specific interaction of pyruvate kinase with hepatitisC virus NS5B. FEBS Lett, 2008, 582( 15 ) : 2155-2160.
  • 4Gatenby RA, Gillies RJ. Why do cancers have high aerobic glyeolysis? Nat Rev Cancer, 2004, 4 (11) :891-899.
  • 5Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumor. Nat Rev Cancer, 2008, 8(9) :705-713.
  • 6Munoz ME, Ponce E. Pyruvate kinase: current status of regulatory and functional properties. Comp Biochem Physiol B Biochem Mol Biol, 2003,135(2) :197-218.
  • 7Stetak A, Veress R, Ovadi J, et al. Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res, 2007,67 (4) : 1602-1608.
  • 8Lee J, Kim HK, Han YM, et al. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription. Int J Biochem Cell Biol, 2008, 40(5) :1043-1054.
  • 9Ignacak J, Stachurska MB. The dual activity of pyruvate kinase type M2 from chromatin extracts of neoplastic cells. Comp Biochem Physiol B Biochem Mol Biol, 2003, 134(3) :425-433.
  • 10Christofk HR, Vander Heiden MG, et al. Pyruvate kinase M2 is a phosphotyrosine binding protein. Nature, 2005, 452 (7184) : 181- 186.

同被引文献27

  • 1Hathurusinghe HR,Goonetilleke KS,Siriwardena AK. Current status of tumor M2 pyruvate kinase ( tumor M2-PK ) as a biomarker of gastroin- testinal malignancy [ J ]. Ann Surg Onco1,2007,14 (10) :2714-2720.
  • 2Mazurek S, Boschek CB, Hugo F, et al. Pyruvate kinase type M2 and its role in tumor growth ang spreading [ J ]. Semin Cancer Biol, 2005, 15(4) :300-308.
  • 3Hitosug T, Kang S, Vander Heiden MG, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth [ J ]. Science Simaalim, .2009.2 ( 97 ) :73.
  • 4Wierzbicka-Patynowski I, Mao Y, Schewarzbauer JE. Continuous re- quirement for pp60-Sre and phospho-paxillin during fibronectin matrix assembly by transformed cell [ J ]. J Cell Physiol, 2007,210 ( 3 ) : 750- 756.
  • 5Mazurek S, Zwerschke W, Jansen DP, et al. Metabolic cooperation be- tween different on cogenes during cell transformation : interaction be- tween activated ras and HPV-16 E7 [ J ]. Oncogene, 2001,20 ( 47 ) : 6891-6898.
  • 6Lee J, Kim HK, Hart YM, et al. Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcrip- tion [ J ]. Int J Biochem Cell Bio1,2008,40 ( 5 ) : 1043-1054.
  • 7Mazurek S, Eigenbrodt E. The tumor metabolome [ J ]. Anticancer Res, 2003,23 (2A) : 1149-1154.
  • 8Mazurek S. Pyruvate kinase type M2 : a key regulator of the metabolic budget system in tumor cells [ J ]. International Journal of Biochemis- try and Cell Biology ,2011,43(7 ) :969-980.
  • 9Luftner D, Mesterharm J, Akrivakis C, et al. Tumgr type M2 pyruvate kinase expression in advanced breast cancer [ J ]. Antieancer Res, 2000,20(6D) :5077-5082.
  • 10Hoopmann M, Warm M, Mallmann P, et al. Tumor M2 pyruvate ki- nase : determination in breast cancer patients receiving trastuzumab therapy [ J ]. Cancer Lett,2002,187 ( 1-2 ) :220-228.

引证文献2

二级引证文献6

国际肿瘤学杂志
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部