摘要
目的：通过观察高压氧（ＨＢＯ）治疗对严重烧伤患者血浆纤维连结蛋白（ｆｉｂｒｏｎｅｃｔｉｎ，Ｆｎ）含量的影响，探讨ＨＢＯ在烧伤治疗中的价值。方法：４２例严重烧伤患者（烧伤总面积大于３０％或３度烧伤面积大于１０％），随机分为ＨＢＯ治疗组（ＨＢＯ组）和非ＨＢＯ治疗组（ｎｏｎ－ＨＢＯ组），于伤后８小时和１、２、３、５、７、１０、１４、１７、２１天１０个时相点抽静脉血，用火箭免疫电泳法测定其血浆Ｆｎ含量。结果：ｎｏｎ－ＨＢＯ组患者伤后各时相点血浆Ｆｎ含量均显著低于正常对照组（Ｐ＜０．０５或Ｐ＜０．０１）；而ＨＢＯ组除伤后８小时及１天外，其余各时相点血浆Ｆｎ含量正常，与ｎｏｎ－ＨＢＯ组比，伤后１０个时相点血浆Ｆｎ含量均显著增高（Ｐ＜０．０５或Ｐ＜０．０１）。结论：ＨＢＯ可明显提高严重烧伤患者血浆Ｆｎ水平，故对烧伤治疗有一定价值。
Aim:To observe the effect of hyperbaric oxygen(HBO) on plasma fibronection(Fn) level in patients with severe burns,so as to verify its therapeutic value.Methods:Forty two patients with burn of more than 30% body surface area or three degree more than 10% area were selected and randomized into two groups:HBO group and non HBO group.Another forty healthy blood donors were selected as normal control.Venous blood samples were drawn from the patients at 1/3,1,2,3,5,7,10,14,17 and 21 days after the burn;the plasma Fn Levels were measured by rocket electrophoresis technique.Results:In non HBO group,the levels of plasma Fn were significantly lower than that of normal control( P <0 05 or P <0 01)at all times measured after the burn,whereas the levels of plasma Fn in HBO group were not remarkably reduced except at 8 h and 1 d after the burn.Furthermore,the levels of plasma Fn in HBO group were signifcantly higher than all those measured in non HBO group after the burn( P <0 05 or P <0 01).Conclusion:HBO can significantly elevate the level of plasma Fn in patients with severe burns and subsequently has a positive effect on the treatment of burns.
