急性脑卒中患者的免疫功能与医院感染

Immunologic function and hospital infection of patients with acute stroke

目的为提高急性脑卒中患者的免疫功能和防治医院感染。方法对４６例脑卒中伴发医院感染患者，采用抗生素及常规药物治疗２３例，与加用纳洛酮治疗２３例，同时观察其外周血淋巴细胞计数、血浆β－内啡肽含量。结果纳洛酮治疗组患者外周血淋巴细胞计数显著高于常规治疗组，而血浆β－内啡肽含量显著低于常规治疗组，医院感染控制时间也明显短于常规治疗组。结论纳洛酮可拮抗β－内啡肽对ＲＢＣ免疫功能的抑制作用，从而提高ＲＢＣ免疫功能。

Objective To increase the immunologic function and prevent and cure hospital infection of patients with acute stroke was studied. Methods We divided 46 cases of stroke patients with hospital infection into two groups. One group control (23 cases) were treated with antibiotics and routine drugs, another group were treated with antibiotics, routine drugs and naloxone. During the period of treatment, we detected both group's peripheral lymhocyte count and the concentration of serum β-endorphin (β-EP). Results The result showed that peripheral lymphocyte count of the group (naloxone group) was higher than control group significantly, the period of hospital infection was shorter obviously. Conclusion This paper indicates that naloxone is able to antagone the effect of inhibition of β-EP to RBC's immunologic function, increase RBC's immunologic function and improve hospital infection finally. 