经静脉六氟化硫葡萄糖白蛋白左心超声造影实验研究

Experimentary Study on Left Ventricular and Myocardial Contrast Echocardiography by Intravenous Injection by Sonicated SF6 Dextrose Albumin Microbubbles

对９条闭胸狗，１条开胸狗经周围静脉分别注射声振葡萄糖白蛋白（ＳＤＡ）及含六氟化硫的声振葡萄糖白蛋白（ＳＤＡ－ＳＦ６），进行左心腔与心肌超声造影。结果：周围静脉注射ＳＤＡ－ＳＦ６５７次，左心腔显影５５次，显影率９６％；注射ＳＤＡ５４次，左心腔显影２７次，显影率５０％。ＳＤＡ－ＳＦ６组和ＳＤＡ组比较：左室持续显影时间分别为１５±２和４±１ｓ（Ｐ值＜０．００１），经肺时间分别为４．５±１．０和５．０±１．０ｓ（Ｐ值＜０．０１），左室显影强度分别为Ⅱ～Ⅲ级和Ⅰ级。心肌显影成功率ＳＤＡ－ＳＦ６为１００％，心肌显影强度为Ⅰ～Ⅱ级，而ＳＤＡ为０。另有４条狗作了主动脉根部非选择性造影，结果两种造影剂的心肌显影均为１００％。

Left ventricular and myocardial contrast echocardiography were performed in 9 closed chest dogs and one open chest dog by intravenous injection of sonicated SF6 dextrose albumin microbubbles (SDASF6) and sonicated dextrose albumin microbubbls (SDA). Left ventricular opacification rate was 96% (55/57) in SDASF6 group, 50% (27/54) in SDA group. The dense contrast persistence time in the left ventricule, the pulmonarytransit time and left ventricular ultrasound videointensity was 15±2s, 4.5±1.0s, Ⅱ￣Ⅲ grade in SDASF6 group; 4±1.0s, 5.0±1s, I grade in SDA group, respectively. There were significant diferences between two groups (P<0.01 or P<0.001). Myocardial opacification rate was 100% in SDASF6 group and the ultrasound videointensity in left ventricular myocardium was Ⅰ￣Ⅱ grade, 0 in SDA group. Contrast agents were injected by the catheter at the root of aorta in another four dogs. Myocardial opacification was 100% and ultrasound videointensity was Ⅲ grade in two groups.