二肽与铜(II)、锌(II)络合物的配位作用

PEPTIDES COMPLEXES OF COPPER(Ⅱ)AND ZINC(Ⅱ)

研究了甘氨酰甘氨酸、甘氨酰缬氨酸、甘氨酰酪氨酸等二肽与二价铜、锌的络合能力、在生理条件下(37℃,I=150mmol·dm^(-3)NaC1),用微量pH电位滴定技术测定了它们的生成常数。实验数据与络合粒子模型的研究是用MINIQUAD和ESTA计算程序处理的。

The complexing abilities of Glycylglycine, Glycyl-d, l-valine and Glycyl-l-tyrosine to divalent copper and zinc ions have been studied. The formation cons-tants of these peptides complexes, as well as protonation constants, have beendetermined using micro-potentiometric titration under physiological conditions(37℃, I=150 mmol·dm^(-8) NaCl). The data treatment and speciation study werecarried out with MINIQUAD and ESTA programs at HONEYWELL DPS-8computer.