组胺受体1和2拮抗药对神经病理性疼痛的疗效

Efficiency of histamine H_1 and H_2 receptor antagonists on neuropathic pain in rats

目的探讨脑室内注射组胺受体拮抗药对神经病理性疼痛大鼠的治疗作用。方法选择左侧坐骨神经部分结扎致神经病理性疼痛大鼠30只,随机均分为五组。对照组(C组)脑室内注射生理盐水;P1、P2组分别注射组胺受体1拮抗药美吡拉敏1.5μg和15μg;R1、R2组注射组胺受体2拮抗药雷尼替丁10μg和100μg,评价注药后痛阈的改变。结果与C组相比,R1、R2组雷尼替丁能显著提高大鼠对机械性刺激的痛阈(P<0.05);且R2组对疼痛的治疗效果加强,时间延长。结论神经病理性疼痛时,采用组胺受体2拮抗药能提高痛阈,缓解疼痛。

Objective To investigate the efficiency of intracerebroventricular injection of histamine receptor antagonists on mechanical pain threshold of neuropathic pain in rats. Methods The neuropathic pain rat model was established by partially ligation of the sciatic nerve in 30 rats. Two weeks later, histamine receptor 1 antagonist pyrilamine 1.5μg or 15μg was injected intracerebroventricularly in group P1 or P2 ,histamine receptor 2 antagonist ranitidine 10μg or 100μg in group R1 or R2, and normal saline in group C as the control. The pain threshold was measured. Results Compaered with group C, the pain threshold was signifigantly increased in group R1 and R2, especially in group R2 （P〈0. 05）. Conclusion Histamine H2 receptor antagonist can increase pain threshold in rats with neuropathic pain.