卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病临床观察

Clinical observation of sequential therapy of calcipotriol cream with halometasone cream in plaque type psoriasis

目的:观察卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病的疗效及安全性。方法:76例银屑病患者随机分为卡泊三醇组(A组)36例和卡泊三醇软膏和卤米松乳膏序贯治疗组(B组)40例,A组患者每日涂药2次,B组患者按银屑病的序贯疗法用药。两组患者在疗后的第2周、4周、6周根据银屑病皮损面积和严重度指数(PASI)评分评判疗效,根据不良事件发生率分析其安全性。结果:随着疗程的增加两组患者的PASI评分均逐渐下降(P<0.01),B组下降更为明显(P<0.05);A组患者在治疗后2周、4周和6周的有效率分别为30.56%、55.56%和66.67%;B组患者的有效率分别为52.50%、67.50%和82.50%,B组的疗效明显优于A组(P<0.01);B组的不良事件发生率亦明显低于A组(P<0.01)。结论:卡泊三醇软膏和卤米松乳膏序贯疗法治疗斑块状银屑病具有起效快、疗效好、不良反应小的优点。

Objective： To observe the efficacy and safety of sequential therapy of combined calcipotriol cream with halometasone cream in the treatment of plaque type psoriasis. Methods： Seventy-six patients with plaque type psoriasis were randomly divided into two groups： 36 patients in group A were treated with calcipotriol cream twicedaily, 40 patients in group B were sequentially treated with calcipotriol cream followed by halometasone cream. The PASI scores were evaluated at the week 2, 4, and 6 after the initiahion of the treatment. The safety of the treatment was evaluated, too. Results： The PASI scores in both groups were decreased with the process of treatment （P 〈 0.01）, with a more decrease in group B （P 〈 0.05）. The effective rates in group B at the week 2, 4, 6 were 52.50%, 67.50% and 82.50% respectively, which were higher that those in group A （ 30.56%, 55.56% and 66.67%） （P〈 0.01）. The incidence of adverse reactions in group B was less than that in group A （P 〈 0.01）. Conclution： There are advantages of the sequential therapy with calcipotriol cream followed by halometasone cream in the treatment of psoriasis： rapid and good response, as well as less adverse reactions.