烧伤患者的焦虑抑郁症状与血浆皮质醇水平的关系

Relationship between the anxiety - depression symptoms and the level of serium cortisone in patients with burn

目的探讨烧伤患者的焦虑抑郁症状与血浆皮质醇水平的关系。方法以烧伤患者33例为研究组，应用汉密顿抑郁量表（HAMD）和汉密顿焦虑量表（HAMA）为工具，于入院后0周、1周末和4周末分别评定烧伤患者的焦虑抑郁症状，并同步测定血浆皮质醇水平，分析焦虑抑郁症状量表分与血浆皮质醇水平的关系，并与本院30例体检者作对照。结果研究组的HAMD、HAMA总分在烧伤急性期（0周和1周末）均显著升高（P〈0．01），好转后恢复至正常水平。与对照组比较，研究组的血浆皮质醇水平在急性期显著升高（P〈0．01），随着烧伤的改善而恢复正常。研究组急性期（0周与1周末之间）血浆皮质醇水平的变化与HAMD、HAMA总分的变化呈正相关。结论烧伤患者在急性期存在不同程度的焦虑抑郁情绪，伴血浆皮质醇水平升高，此期需给予相应的药物治疗和心理干预。

Objective To explore the the relationship between the anxiety -depression symptoms and the level of serium cortisone in patients with burn. Methods Totally 33 patients with burn （the study group） were evaluated with Hamilton depression scale （HAMD）, Hamilton anxiety scale （HAMA） before treatment,after 1 week and after 4 weeks of treatment, at the same time, tested the level of serium cortisone ,with 30 normal controls. Results During acute period, patients with burn had higher scores of HAMD and HAMA （ P 〈0.01 ） and decreased to normal level after recovery. Compared with the control group,the serium cortisone of burn patients significantly increased during acute period （ P 〈 0.01 ） and recovered with burn improvement. There showed significant positive correlation between the changes of serium cortisone and the changes of the total scores of HAMD and HAMA in the study group during acute period. Conclusions During acute period, burn patients have some extent anxiety -depression symptoms with higher level of serium cortisone. This need drug - treatment and psychological interventions respectively.