辛伐他汀对慢性肾功能衰竭患者炎性反应的影响

Effect of simvastatin on inflammatory reaction in chronic renal failure patients

目的观察慢性肾功能衰竭（CRF）患者C-反应蛋白（CRP）、纤维蛋白原（Fg）的变化，探讨辛伐他汀对CRF患者炎性反应的影响。方法将54例CRF患者随机平均分为两组：非他汀组（27例）予常规治疗；他汀组（27例）予常规治疗加辛伐他汀20mg／d。同时设健康对照组20例。测定各组治疗前和治疗4周后CRP、Fg水平。结果CRF患者治疗前CRP、Vg显著高于对照组，差异有统计学意义（P〈0．05）。治疗4周后，辛伐他汀组CRP、Vg水平下降，与治疗前及同期非他汀相比，差异有统计学意义（P〈0．05）。结论①CRF患者中存在CRP水平升高的炎性反应；②辛伐他汀可以降低CRP、Fg水平，提示其具有降脂以外的抗炎作用。

Objective To observe the changes of serum CRP and plasma Fg in patients with chronic renal failure（ CRF）, and to explore the effect of simvastatin on inflammatory reaction in CRF patients.Methods Fifty -Four patients with CRF were randomly divided into non -statins group（ routine therapy） and statins group[ routine therapy plus simvastatin （20 mg/d）]. Besides,a healthy control group consisted of 20 subjects was set up as control group. The changes of serum of CRP and plasma Fg of all groups before and four weeks after treatment were recorded. Results The serum CRP and plasma Fg levels increased in CRF patients,which were significantly higher as compared to the control group. After treatment for four weeks,the level of CRP, Fg of simvastatin group decreased significantly. The levels of CRP, Fg had no statistical changes in non -statins group. As compared to non -statins group, the differences of CRP, Fg Ievels after treatment in simvastatin group were statistically significant respectively. Conclusions ①Inflammaory reaction is a common condition in non- dialysis patients with CRF;②Simvastatin show effects on decrease of CRP, Fg level in CRF patients,independently on the effect of decreasing hyperlipemia.