青春期和成年期多囊卵巢综合征胰岛素抵抗情况分析

Analysis of insulin resistance in adolescence and adulthood patients with polycystic ovarian syndrome

目的:探讨青春期和成年期多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者的胰岛素抵抗(insulin resistance,IR)情况。方法:采用空腹血糖与空腹胰岛素比值和稳态模式评估法评估胰岛素抵抗指数来评价30例青春期PCOS患者(青春期组)及30例成年期PCOS患者(成年组)的IR情况。结果与结论:青春期组患者空腹、餐后1 h、餐后2 h和餐后3 h的血糖水平较成年组低,而胰岛素水平较成年组高(均为P<0.05);青春期组的IR发生率为63%,成年组的IR发生率为33%,2组比较差异有统计学意义(P<0.05)。青春期PCOS患者IR发生率高,提示对青春期PCOS患者应及早行IR检测,以及时确诊与治疗。

Objective： To study the insulin resistance （IR） in adolescence and adulthood patients with polycystic ovarian syndrome （PCOS）. Methods： IR in 30 adolescence with PCOS （adolescence group）and 30 adulthood with PCOS （adulthood group） was evaluated by the ratio of fasting blood glucose to insulin, and homeostasis model assessment. Results and Conclusion： Adolescence group had lower blood glucose and higher insulin level at fasting and 1 hour, 2 hours and 3 hours after meal compared with adulthood group（ P〈0. 05 ）. The incidence rate of IR in adolescence group was 63%, the incidence rate of IR in adulthood group was 33%, there was significant difference in two groups （ P 〈 0. 05 ）. Higher IR incidence rate in adolescence PCOS patients suggests that IR should be detected in adolescence PCOS patients as soon as possible for diagnosis and treatment in time.