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糖尿病性类脂质渐进性坏死的发病机制和治疗进展 被引量：3

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摘要 从微血管病变、免疫病理、葡萄糖转运以及癌基因表达、遗传等方面探讨糖尿病性类脂质渐进性坏死的发病机制。从作用原理来分,治疗药物主要分为改善皮肤血流学、抗炎治疗(包括糖皮质激素、免疫调节剂、生物制剂等)、促进伤口愈合的药物以及物理疗法、外科手术等。
作者 浦洁 张美华
机构地区 南京医科大学附属无锡人民医院 江苏省人民医院(南京医科大学第一附属医院)
出处 《中国麻风皮肤病杂志》 2009年第5期366-368,共3页 China Journal of Leprosy and Skin Diseases
关键词 糖尿病性类脂质渐进性坏死 发病机制 治疗
分类号 R587.2 [医药卫生—内分泌] R979.1 [医药卫生—药品]
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参考文献20

  • 1Ngo B,Wigington G,Hayes K,et al.Skin blood flow in necrobiosis lipoidica diabeticorum.Int J Dermatol 2008;47(4):354-358.
  • 2Eisendle K,Baltaci M,Kutzner H,et al.Detection of spirochaetal microorganisms by focus floating microscopy in necrobiosis lipoidica in patients from central Europe.Histopathology 2008;52:877-884.
  • 3Macaron NC,Cohen C,Chen SC,et al.gli-1 Oncogene is highly expressed in granulomatous skin disorders,including sarcoidosis,granuloma annulare,and necrobiosis lipoidica diabeticorum.Arch Dermatol 2005;141(2):259-262.
  • 4Holland C,Givens V,Smoller BR.Expression of the human erythrocyte glucose transporter Glut-1 in areas of sclerotic collagen in necrobiosis lipoidica.J Cutan Pathol 2001;28(6):287-290.
  • 5Shimanovich I,Erdmann H,Grabbe J,et al.Necrobiosis lipoidica in monozygotic twins.Arch Dermatol 2008;144(1):119-120.
  • 6Basaria S,Braga-Basaria M.Necrobiosis lipoidica diabeticorum:response to pentoxiphylline.J Endocrinol Invest 2003;26:1037-1040.
  • 7Tan E,Patel V,Berth-Jones J.Systemic corticosteroids for the outpatient treatment of necrobiosis lipoidica in a diabetic patient.J Dermatolog Treat 2007;18(4):246-248.
  • 8Clayton TH,Harrison PV.Successful treatment of chronic ulcerated necrobiosis lipoidica with 0.1% topical tacrolimus ointment.Br J Dermatol 2005;152(3):581-582.
  • 9Kolde G,Muche JM,Schulze P,et al.Infliximab:a promising new treatment option for ulcerated necrobiosis lipoidica.Dermatology 2003;206:180-181.
  • 10Evans AV,Atherton DJ.Recalcitrant ulcers in necrobiosis lipoidica diabeticorum healed by topical granulocyte-macrophage colony-stimulating factor.Br J Dermatol 2002;147:1023-1025.

同被引文献49

  • 1张晓菲,郝飞.糖尿病皮肤病变临床诊断的进展[J].实用皮肤病学杂志,2009,2(1):31-34. 被引量：15
  • 2王维萍,袁南兵,王椿,王艳,余婷婷,吴雪艳,冉兴无.一例糖尿病性类脂质渐进性坏死左小腿皮肤溃疡患者的循证治疗[J].中国循证医学杂志,2007,7(11):830-835. 被引量：7
  • 3Chakrabarty A, Norman RA, Phillips T. Cutaneous manifestations of diabetes [J]. Wounds, 2002, 14 (8) : 267-274.
  • 4Dissemond J. Images in clinical medicine. Necrobiosis lipoidica diabeticorum [J]. N Engl J Med, 2012, 366 (26): 2502.
  • 5Muller SA, Winkelmann RK. Necrobiosis lipoidica diabeticorum. A clinical and pathological investigation of 171 cases [J]. Arch Dermatol, 1966, 93 (3) : 272-281.
  • 6O'Toole EA, Kennedy U, Nolan JJ, et al. Necrobiosis lipoidica:only a minority of patients have diabetes mellitus [J]. Br J Dermatol, 1999, 140 (2):283-286.
  • 7Kapoor S. Diagnosis and treatment of acanthosis nigricans [J]. Skinmed, 2010, 8 (3): 161-164.
  • 8Levy L, Zeichner JA. Dermatologic manifestation of diabetes [J]. J Diabetes, 2012, 4 (1): 68-76.
  • 9Pi6rard GE, Seit6 S, Hermanns-L~ T, et al. The skin landscape in diabetes mellitus. Focus on derrnocosmetic management [J]. Clin Cosmet Investig Dermatol, 2013, 6 (5) : 127-135.
  • 10Romo A, Benavides S. Treatment options in insulin resistance obesity-related acanthosis nigricans [J~. Ann Pbarmacother, 2008, 42 (7) : 1090-1094.

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中国麻风皮肤病杂志
2009年 第5期

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