肺动脉高压治疗新药——西地那非

New drug for treatment of pulmonary arterial hypertension—sildenafil

前列环素类似物、内皮素受体拮抗药和磷酸二酯酶抑制药是目前肺动脉高压治疗的最新、最有效的3类药物。西地那非是一个选择性的磷酸二酯酶抑制药,它通过抑制磷酸二酯酶而发挥扩张肺血管作用。临床研究表明西地那非可改善临床症状、提高运动耐量。西地那非具有服用方便、不良反应少等优点。

Prostanoids, endothelin-receptor antagonists, and phosphodiesterase inhibitors are 3 types of the newest, most potent drugs for the treatment of pulmonary arterial hypertension nowadays. Sildenafil is a selective phosphodiesterase inhibitor with pulmonary vessel dilating effect through inhibiting phosphodiesterase. Clinical study indicated sildenafil may improve clinical symptom, increase exercise with further more of easy taking and less adverse reaction, etc.