细胞间黏附分子1在溃疡性结肠炎诊治中的临床意义

Clinical significance of intercellular adhesion molecule-1 in ulcerative colitis

目的探讨血清细胞间黏附分子1(ICAM-1)水平在溃疡性结肠炎(UC)中的临床意义。方法收集30例UC患者(UC组)及30例正常者(C组)的血清,分别以ELISA法及免疫速率比浊法检测血清ICAM-1及C反应蛋白(CRP)水平。结果UC组ICAM-1的水平明显高于C组(P<0.05);同一患者UC活动期ICAM-1高于缓解期(P<0.05);ICAM-1水平升高与UC疾病活动度的严重程度呈正相关(P<0.05),而与UC发生部位无关(P>0.05);ICAM-1与CRP有良好一致性(r=0.8)。结论UC患者血清ICAM-1水平升高与疾病活动度呈正相关,可作为UC疾病活动度和判断治疗效果的一个客观指标。

Objective To study the clinical significance of the serum intercellular adhesion molecule-1 （ICAM-1） level in the patients with ulcerative colitis（UC）. Methods Serum ICAM-1 and CRP of 30 UC patients and 30 normal controls were detected with ELISA and immunization rate turbidimetry. Results Serum ICAM-1 level in UC patients was significantly higher than that in normal controls （P〈0.05）. Serum ICAM-1 level in the active phase was significantly higher than that in the remission phase in the same patients （P〈0.05）. ICAM-1 was positively correlated with the severity of the activity of UC （P〈0. 05）, which was not correlated with lesion locations （P〉 0. 05）. There was a good consistency between ICAM-1 and CRP （r= 0.8）. Conclusion Serum ICAM-1 level was higher in UC patients and positively correlated with disease severity,which may be taken as one of the objective indicators for evaluating the UC activity and therapeutic efficacy.