基因工程人白细胞介素-2治疗恶性浆膜腔积液57例疗效观察

The results of 57 cases with malignant serous effusion treated with genic engineering human interleukin2

目的：评价基因工程人白细胞介素－２（ｒｉＬ－２）治疗恶性浆膜腔积液疗效。方法：作者对接受ｒｉＬ－２治疗的５７例恶性浆膜腔积液进行了回顾性研究。其中恶性胸膜腔积液５２例（Ａ组），恶性腹膜腔积液４例（Ｂ组），恶性心包腔积液１例（Ｃ组），Ａ、Ｂ、Ｃ组腔内注射剂量分别为３０～５０万单位、５０～１００万单位、１００万单位，每周注射１～２次，连续作２～４周。结果：Ａ组ＣＲ率为５１．９％（２７／５２），ＰＲ率为３０．７％（１６／５２），总有效率（ＣＲ＋ＰＲ）为８２．６％（４３／５２），癌细胞阴转率为７４．４％（３２／４３）；Ｂ组１例达ＰＲ，有效率为２５％（１／４）；Ｃ组１例治疗后达ＣＲ。主要的不良反应为发热、胸痛、胃肠道反应，但均较轻。结论：白细胞介素－２具有疗效好。

Object: To evaluate the curative effect of malignant serous effusion treated with genic engineering human interleukin2Methods:From August 1993 to December 1996, 57 cases with malignant serous effusion were studied retrospectively, of them 52 cases malignant pleural effusion(group A),4 cases malignant peritoneal effusion(group B) and 1 case percardial effusion (group C).The dosage for three group were 30×104～50×104U,50×104～100×104U,100×104U intracavity injection,respectively once or twice a week for 2～4 weeks, Results:In group 1,CR rate 519%(27/52),PR rate 307%(16/52),the total effective rate (CR+PR) were 826%(43/52),the negtive conversion rate of cancer cell in pleural effusion was 744%(32/43);In group2,PR 25% (1/4);and in group3,1 case cured after treatment, and reached CR.The major side effect is low grade fever,mild chest pain and slight gastrointestinal discomfort,In conclusion:IL2 has characteristics of the good curative effect and low side effect.