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IL-21的研究进展 被引量：5

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摘要 IL-21主要由活化的CD4+T细胞、NKT细胞和Th17细胞产生,其受体属I型细胞因子受体家族成员之一,具有共同的γ链受体,即γc。IL-21对机体的细胞免疫和体液免疫均具有广泛的调节作用,主要表现为促进B细胞向浆细胞分化,调节免疫球蛋白的产生;增强CTL的细胞毒活性;促进初始CD4+T细胞向Th17细胞分化;抑制树突状细胞(DC)的抗原提呈作用。此外,IL-21具有潜在的抗肿瘤效应,在自身免疫性疾病中也起到了一定的作用。因此,进一步了解IL-21的特性和功能对深入研究临床疾病的发生发展具有重要的意义。
作者 林锦骠 李宁丽
机构地区 上海交通大学医学院上海市免疫学研究所
出处 《现代免疫学》 CAS CSCD 北大核心 2009年第3期255-258,共4页 Current Immunology
基金 国家自然科学基金资助项目(30671945 30872990) 上海市科委资助项目(08JC1413200 08ZR1412400)
关键词 IL-21 自身免疫 分化 TH17细胞 肿瘤 TREG 变态反应
分类号 R392.12 [医药卫生—免疫学]
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参考文献20

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同被引文献65

  • 1仲艳敏,林羿,李莉平,Nisar Khan,狄静芳,曾山,Robbert Benner.人工合成相关寡肽抑制poly I:C诱发性流产的作用[J].现代免疫学,2007,27(2):145-150. 被引量：9
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  • 7ELSAESSER H,SAUER K,BROOKS D G.IL-21 is required to control chronic viral infection[J].Science,2009,324(5934):1569-1572.
  • 8FRHLICH A,KISIELOW J,SCHMITZ I,et al.IL-21R on T cells is critical for sustained functionality and control of chronic viral infection[J].Science,2009,324(5934):1576-1580.
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引证文献5

二级引证文献13

现代免疫学
2009年 第3期

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