重型再生障碍性贫血患者血清G-CSF水平的变化

Serum level of granulocyte colony stimulating factor in severe aplastic anemia patients

目的：观察重型再生障碍性贫血－Ⅰ型（ＳＡＡ－Ⅰ型）患者血清粒细胞集落刺激因子（Ｇ－ＣＳＦ）水平的变化及其与病情、疗效和预后的关系。方法：采用酶联免疫法对ＳＡＡ－Ⅰ型患者治疗前血清和治疗过程中Ｇ－ＣＳＦ水平进行检测。结果：３６例ＳＡＡ－Ⅰ型患者中２７例（７５％）治疗前血清Ｇ－ＣＳＦ水平高于正常，与血清Ｇ－ＣＳＦ水平正常患者相比较，后者达到治疗有效所需疗程较短，且疗效较好；对７例患者进行动态观察显示，随着病情逐渐好转，患者血清Ｇ－ＣＳＦ水平逐渐恢复正常。结论：检测重型再生障碍性贫血患者血清Ｇ－ＣＳＦ水平有助于判断患者的病情及预测其预后。

Objective: To investigate the relationship between serum level of granulocyte colony stimulating factor (GCSF) and clinical status, treatment outcome and prognosis in severe aplastic anemia(SAAⅠ) patients. Methods: Serum GCSF level was detected by ELISA assay in 36 SAAⅠ patients. Results: Pretreatment serum GCSF levels of 27/36 (75%) SAAⅠ patients were above normal. These patients achieved better curative outcomes in a shorter period of treatment. Conclusion: Detection of serum GCSF level in SAAⅠ patients is helpful for judging the clinical status and prognosis.