摘要
目的:观察重型再生障碍性贫血-Ⅰ型(SAA-Ⅰ型)患者血清粒细胞集落刺激因子(G-CSF)水平的变化及其与病情、疗效和预后的关系。方法:采用酶联免疫法对SAA-Ⅰ型患者治疗前血清和治疗过程中G-CSF水平进行检测。结果:36例SAA-Ⅰ型患者中27例(75%)治疗前血清G-CSF水平高于正常,与血清G-CSF水平正常患者相比较,后者达到治疗有效所需疗程较短,且疗效较好;对7例患者进行动态观察显示,随着病情逐渐好转,患者血清G-CSF水平逐渐恢复正常。结论:检测重型再生障碍性贫血患者血清G-CSF水平有助于判断患者的病情及预测其预后。
Objective: To investigate the relationship between serum level of granulocyte colony stimulating factor (GCSF) and clinical status, treatment outcome and prognosis in severe aplastic anemia(SAAⅠ) patients. Methods: Serum GCSF level was detected by ELISA assay in 36 SAAⅠ patients. Results: Pretreatment serum GCSF levels of 27/36 (75%) SAAⅠ patients were above normal. These patients achieved better curative outcomes in a shorter period of treatment. Conclusion: Detection of serum GCSF level in SAAⅠ patients is helpful for judging the clinical status and prognosis.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
1998年第4期186-188,共3页
Chinese Journal of Hematology