多裂骆驼蓬化学成分研究 Ⅰ.种子生物碱类成分及其抗肿瘤活性

Studies on the Chemical Constituents of Peganum multisectum Maxim Ⅰ The Alkaloids from Seeds and Antitumour Activity

首次从我国特有植物多裂骆驼蓬种子总生物碱中分离得到了９个化合物，鉴定了７个，其中６个为生物碱，分别为去氢骆驼蓬碱（Ⅰ），哈尔醇（Ⅱ），哈梅林（Ⅲ），鸭嘴花碱（Ⅳ），鸭嘴花酮碱（Ⅴ），脱氧鸭嘴花酮碱（Ⅵ），另一个化合物为苯甲酸（Ⅶ）。并对主成分Ⅰ进行了Ｋ５６２人白血病细胞生长抑制作用的体外细胞毒研究，结果表明去氢骆驼蓬碱对Ｋ５６２白血病细胞有明显的抑制和杀灭作用，活性指数超过环磷酰胺。

Six alkaloids, harmine( Ⅰ)、 harmol( Ⅱ)、 harmaline( Ⅲ)、vasicine( Ⅳ)、 vasicinone( Ⅴ)、 deoxyvasicione( Ⅵ) together with benzoic acid( Ⅶ) was isolated from the total alkaloid part of seeds of Peganum multisectum Maxim The structure was identified by means of UV, IR, MS, NMR spectra All the five compounds in this plant were first reported Also the present paper reported the cytotoxcity effect of isolated compounds on K562 leukaemia cell The results showed that harmine exhibited the potent antitumour activity