四环素控释药线的研究

Study on Controlled Release Tetracyclinecontaining Fibers

以乙烯醋酸乙烯聚酯为载体研制出治疗牙周炎的控释药线。释药行为试验表明四环素自药线中的释药过程符合Ｈｉｇｕｃｈｉ方程。药线释药可超过８ｄ。释药过程受药线外径的影响，外径大的药线有较长的释药时间和维持有效药物浓度的时间。同时观察了温度和湿度对药线的影响。

For the purpose of prolongable antibacterial effect for the periodontol therapy, controlled delivery tetracyclinecontaining fibers were manufactured using ethylene vinyl acetate The test of ability to sustain long term drug release was performed Results showed that in vitro release of tetracycline from fibers was in accordance with Higuchi equation, and fibers provide drug release for the period of more than eight days, and fibers with the larger diameter could carry the more drug and could provide the longer release period