牛初乳复合细胞营养因子对免疫功能的影响

Effect of Cell Health Factors from Bovine Colostrum on Immune System

牛初乳复合细胞营养因子（ＣＨＦ，２．５，５．０，１０．０，２０．０μｇ／ｍｌ）可促进ＣｏｎＡ活化的小鼠脾淋巴细胞ＤＮＡ生物合成。小剂量（２０ｍｇ／ｋｇ）口服对２，４，６－三硝基氯苯所致小鼠迟发型变态反应（ＰＣ－ＤＴＨ）有增加作用，２０和４０ｍｇ／ｋｇ给药组对氢化泼尼松所致ＰＣ－ＤＴＨ的抑制可使其恢复至正常水平。ＣＨＦ（２０和４０ｍｇ／ｋｇ口服）对正常小鼠血清溶血素含量有增强作用，对于环磷酰胺所致的抗体产生抑制作用也有一定的恢复作用；大剂量（８０ｍｇ／ｋｇ）还可增加小鼠的碳粒廓清速率，表明ＣＨＦ对细胞免疫有促进作用，能减轻或防止糖皮质激素类药物的免疫抑制作用；对体液免疫和巨噬细胞吞噬功能也有促进作用。

The effect of cell health factors(CHF) from bovine colostrum on immune system was studied in this paper. The results showed that at the concentration of 2.5, 5.0, 10.0, 20.0 μg/ ml, CHF can improve the DNA synthesis of mice spleen lymphocytes with ConA stimulation. With the dose of 20 mg/kg by po, CHF can increase the PCDTH and recovery the imhibition of PCDTH by prednisoloni. CHF also can increase the production of hemolysins; recover the inhibition of hemolysin production by cyclophosphamidum and increase the clearance rate of carbon particles with the dose of 20, 40, 80 mg/kg. It suggested that CHF has a strong effect on immune system.