应用光学相干断层扫描仪检测垂体瘤患者视网膜神经纤维层厚度

Optical coherence tomography in measuring retinal nerve fiber layer thickness in pituitary tumor

目的:探讨光学相干断层扫描仪(optical coherence tomography,OCT)测量视网膜神经纤维层厚度(retinal nerve fiber layer,RNFL)在垂体瘤患者诊断与视功能预后分析中的意义。方法:应用OCT测量正常人76例(76眼)和垂体瘤患者39例(39眼)的各象限和平均RNFL厚度进行比较并计算平均RNFL厚度和视野平均缺损的相关性。结果:垂体瘤患者各象限和平均RNFL厚度均比正常人减少,差异有统计学意义(P<0.000)。平均RNFL厚度和视野平均缺损呈正相关(R=0.41,P=0.000)。结论:OCT测量RNFL厚度为临床上垂体瘤的诊断提供了一种新的手段。

Objective：To evaluate the significance of the retinal nerve fiber layer （RNFL） thickness measured by optical coherence tomography （OCT） in the diagnosis and prognosis of visual function of pituitary tumor. Methods：The thickness of RNFL was measured by OCT in 39 patients with pituitary tumor （39 eyes） and 76 normal subjects（76 eyes）. Comparisons were made with regard to the RNFL thickness of quadrants and in means between normal and pituitary tumor group. The correlation between mean RNFL thickness and mean defect of visual field. Results：There was significant difference of RNFL thickness in various quadrants and in means between normal and pituitary tumor group （P 〈 0.000）.The mean RNFL thickness was positively correlated with mean defect of visual field （R=0.41,P=0.000）. Conclusion：RNFL thickness measured by OCT provides a new method for the diagnosis of pituitary tumor.