氨酚羟考酮治疗中重度癌痛不良反应的临床观察

Adverse effects of oxycodone-acetaminophen tablet during the treatment of moderate or severe cancer pain

目的:观察氨酚羟考酮治疗中重度癌痛患者的不良反应。方法:选取60例中重度癌痛患者,予以口服氨酚羟考酮片,每次1片,q6h,连用7d。结果:氨酚羟考酮常见的不良反应有头晕(7例)、嗜睡(1例)、胃部不适(2例)、恶心呕吐(2例)和便秘(2例)。结论:氨酚羟考酮不良反应发生率较低,是临床药物治疗中重度癌痛的一个较好的选择。

Objective： To observe the adverse effects of oxycodone-acetaminophen tablet during the treatment of moderate or severe cancer pain. Methods： Patients with moderate or severe cancer pain （ n = 60） were treated with 1 tablet of oxycodone-acetaminophen every 6 h for 7 days. Results： The common adverse effects of oxycodone-acetaminophen tablet concluded dizziness （7 patients） , drowsiness （1 patient） , stomach discomfort （2 patients） , nausea and vomiting （2 patients） and constipation （2 patients）. Conclusion ： Oxycodone-acetaminophen tablet has lower adverse effects, and it is one of choices in the treatment of moderate or severe cancer pain in clinic.