氨酚羟考酮治疗中重度癌痛的临床观察

Analgesic effect of oxycodone-acetaminophen on moderate to severe cancer pain

目的:观察氨酚羟考酮片对中重度癌痛的镇痛效果和不良反应。方法:口服氨酚羟考酮对52例中重度癌痛患者进行止痛治疗,每次1～2粒,每日3～4次,间隔4～6h1次。服用最大剂量24h后进行止痛效果评估。结果:氨酚羟考酮对于恶性肿瘤引起的中度和重度急慢性疼痛的总有效率可达80.8%(42/52)。对中度急慢性疼痛的有效率94.1%(32/34),明显高于重度急慢性疼痛的有效率55.6%(10/18)(P<0.05)。结论:氨酚羟考酮对中度癌痛有良好的镇痛效果。

Objective： To observe the analgesic effect and adverse reactions of oxyeodone-aeetaminophen tablet in the treatment of moderate to severe caner pain. Methods： Fifty-two patients （34 with moderate and 18 with severe caner pain） were enrolled in this study. The patients took 1 or 2 tablets of oxycodone-aeetaminophen at intervals of 4 -6 h （3 to 4 times a day）. The analgesic effect was evaluated 24 h after taking the maximal doses. Results： The total effective rate was 80.8% （42/52）. The effective rate （94.1% , 32/34） in patients with moderate pain was significantly higher than that （55.6% , 10/18） in patients with severe pain. Conclusion： Oxycodone-acetaminophen is definitely effective on moderate cancer pain with slight adverse reactions.