口服氨酚羟考酮治疗中重度晚期癌症患者内脏痛的疗效和安全性评价

Efficacy and safety of oxycodone-acetaminophen for moderate and severe visceral pain in advanced cancer patients

目的:评价口服氨酚羟考酮治疗中重度晚期癌症患者内脏痛的疗效和安全性。方法:采用随机对照试验,将70例中重度晚期癌症内脏痛患者随机分为试验组和对照组,试验组口服氨酚羟考酮片(n=35),对照组口服缓释吗啡片(n=35);分别于用药后d1,3,7观察两组患者的镇痛效果和不良反应。结果:两组患者均获得良好的镇痛疗效,并且不良反应发生率较低。结论:氨酚羟考酮对于中重度晚期癌症内脏痛有良好的镇痛效果。

Objective： To evaluate the analgesic effect and safety of oral oxycodone-acetaminophen for moderate and severe visceral pain in advanced cancer patients. Methods： In a randomized and eontrolled trial, 70 advanced cancer patients with moderate to severe visceral pain were randomly divided into 2 groups. The patients were treated with either oral oxycodone-acetaminophen tablet （ n = 35, test group） or oral sustained-release morphine tablet （rt = 35, control group）. The analgesic effect and adverse reactions were observed 1 , 3 and 7 days after the treatments. Results ： A satisfactory analgesic effect and a lower incidence of adverse reactions were found in both groups. Conclusion： Oxycodone-acetaminophen is a safe and effective analgesic drug for moderate to severe visceral pain in advanced cancer patients.