α-细辛醚的黏胶分散型经皮贴剂研究

Study on α-Asaronum drug-in-adhesive transdermal patch

目的:研究α-细辛醚黏胶分散型经皮贴剂制备及其体外释放及透皮性质。方法:采用Eudragit E100为压敏胶材料制备α-细辛醚黏胶分散型贴剂,并筛选出最佳贴剂处方,进行黏附性和释放试验研究,并用Franz扩散池体外评价不同透皮促渗剂对皮肤的渗透情况。结果:所筛选得到药物黏胶分散型贴剂对皮肤无刺激性,合用油酸和肉豆蔻酸异丙酯可显著提高贴剂的透皮效果,药物最大渗透速率为(1.41±0.20)μg·cm-2·h-1。结论:以Eudragit E100为压敏胶材料,油酸、肉豆蔻酸异丙酯为联合促渗剂,制得的α-细辛醚的黏胶分散型经皮贴剂,有望满足临床的治疗要求。

Objective：To prepare α-Asaronum drug-in-adhesive transdermal patch and investigate its release and transdermal absorption characteristics in vitro. Methods ： The drug-in-adhesive transdermal patch of at-Asaronum was developed using Eudragit E100 as PSA matrix. The adhesive performance and release profiles were de- termined. The Franz diffusion cells were used and permeation enhances were evaluated in vitro,Results：The drugin-adhesive patch was not irritating. Oleic aeid （OA） cooperated with Isopropyl Myristate （IPM） showed the improved effect on permeation of the patch. The permeation rate reached （ 1.41 ± 0.20））μg·cm^-2·h^-1 Conclusion ： OA combined with IPM is good permeation enhancer,which facilitated the permeation of α-Asaronum to fit the clinical requirements. However,the further study of the bioavailability is needed.