高母源抗体水平下新城疫常用免疫程序免疫效果研究

Study on Immune Effect of Newcastle Disease Commonly Used Immunization Program under the High Maternal Antibody Titer

在高母源抗体下,对商品肉鸡4种新城疫常用免疫程序的效果进行了检测研究,结果4个免疫组在首免后母源抗体水平都有明显下降,组内变化不明显,但组间变化差异明显。二免后,活苗组仍然受到母源抗体的较大干扰,至55日龄时抗体滴度都在保护水平(6log2)以下,但7日龄组高于3日龄组。而死苗+活苗组受母源抗体的干扰相对较小,3日龄组在50日龄抗体水平可达6log2以上,7日龄组在45日龄达到6.4log2,50日龄升至7log2,并维持至试验结束。7日龄组较3日龄组提前5 d达到抗体保护水平,且抗体滴度相对较高。

Effect of four commonly used immunization program of Newcastle disease in commercial broiler were detected under the high maternal antibody titer, the results indicated that the level of maternal antibody had decreased significantly, the change was not significant in group but significant between groups. After the second inoculation, maternal antibody still had great interference with the live vaccine group, the antibody titer below the protection level（6log2） at 55 days old, but the antibody titer of the 7-day-old group higher than 3-day-old group. Maternal antibody had small interference with the group used both inactivated vaccine and live vaccine, antibody level of 3-day-old group up to 6log2 at 50 days old while antibody level of 7- day-old group up to 6.4log2 at 45 days old and rose to 7log2 at 50 days old and maintained to the end of trial. The antibody level of 7-day-old group which was about five days ahead of schedule to achieve the level of antibody protection was higher than the 3-day-old group.