老年高血压病患者的高胰岛素血症与血脂及血管紧张素的关系

Relationship between Hyperinsulinemia and Angiotensin in the Aged Patients with Hypertension

目的探讨老年高血压病的高胰岛素血症（ＨＩＳ）与血脂及血管紧张素（Ａｎｇ）的关系。方法比较４８例老年高血压病患者和５４例老年非高血压病患者空腹血糖、胰岛素、总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白（ＨＤＬ）、ＡｎｇＩ、Ⅱ水平。结果老年高血压病组空腹胰岛素显著高于非高血压病组（Ｐ＜０．０１）；高血压病组ＴＧ、ＡｎｇⅡ显著增高（Ｐ＜０．０５）；高血压病组血糖、ＴＣ、ＨＤＬ、ＡｎｇⅠ与非高血压病组无明显差异（Ｐ＞０．０５）。结论老年高血压病患者存在ＨＩＳ，且脂质代谢异常，伴有ＡｎｇⅡ升高。

Objective To investigate the relationship between hyperinsulinemia(HIS) and angiotensin(Ang) in the aged patients with hypertension  Methods  The levels of the blood glucose ,serum insulin, total cholesterol(TC), triglycerides(TG), high density lipoprotein(HDL), angiotensin Ⅰ and angiotensin Ⅱ of all subjects, including 48 aged hypertensions and 54 aged normotensives were measured and the results were compared Results No significant difference in the blood glucose, TC, HDL and Ang Ⅰ(P>0 05) was found between the groups of hypertension and normotensive The serum insulin, TG and Ang Ⅱlevels in the aged hypertension group are higher than those in the aged normotensive group (P<0 01, P<0 05 and P<0 05, respectively)  Conclusions The aged patients with hypertension have the high concentration of serum insulin, TG and AngⅡ, but their blood glucose level is normal