蝮蛇抗栓酶治疗银屑病产生耐受性原因探讨

Study of Drug Resistance Produced in Treatment of Psoriasis with Cobra Anti thromboclastic Enzyme

目的通过治疗银屑病５０例临床观察，探讨部分病例未能治愈与机体对蝮蛇抗栓酶产生耐受性原因分析。方法用蝮蛇杭栓酶０．７５ＩＵ加入生理盐水中静滴，治疗前、后及各疗程间监测血小板计数与血浆纤维蛋白原变化。结果药效消失后，血小板计数与血浆纤维蛋白原增高超过治疗前水平。结论该类药物治疗其他血栓性疾病可将血小板计数与血浆纤维蛋白原增高作为药效消失及耐受性产生的一项指标。

Objectives To investigate the correlation between the ineffective treatment of some psoriasis patients and the tolerability of Svate Methods 0 75 IU Svate intravenous dripping was applied in NS to observe the chang of platelet count and plasma fibrinogen, before, during and after the treatment Results After the drug effect vanish,the level of platelet count and fibrinogen were much higher than those before treatment Conclusion The level of platelet count and plasma fibrinogen may be a potential index of the drug tolerbility and ineffectiveness of anti thrombotic drug