紫玉盘化学成分的研究

A Study of Seco-Cyclohexene Oxides in the Stems of Uvaria Macrophylla Var. Microcarpa

目的:从紫玉盘Uvaria macrophylla var. microcarpa中分离具有抗癌活性成分。方法:用色谱方法分离紫玉盘中化学成分,用波谱技术(IR,ESI-MS,1H-NMR,13C-NMR,HMQC,COSY,HMBC,NOESY)进行鉴定结构。结果:从紫玉盘中分离得到4个化合物,uvarimacrins A(1),B(2)and C(4)和uvamalols D(3)。结论:化合物(1),(2),(4)均为新化合物,(3)首次从紫玉盘中分离得到。

This is a study to determine the active anti-cancer constituents in Uvaria macrophylla var. microcarpa. In the study, compounds were isolated and purified using different column chromatographic techniques, and their structures were elucidated based on the spectral data and through comparing with known compounds. As a result, four secocyclohexene oxides were isolated and identified, including three new compounds named as uvarimacrins A （1）, B （2） and C （4）, and a known ingredients uvamalols D （3）, were also isolated from the stems of Uvaria macrophylla var. microcarpa. It is believed that Uvarimacrins A （1）, B （2） and C （4） were the new compounds. Compound （3） was found for the first time in Uvaria macrophylla var. microcarpa.