依赖利福平的肺结核112例临床分析

Clinical Analysis of pulmonary tuberculosis in 112 cases cause by-depending strains

目的探讨依赖利福平分枝杆菌肺结核的临床特点。方法对门诊涂阳患者的痰培养及药敏筛选出一组依赖利福平分枝杆菌肺结核病112例,结合临床加以分析。结果112例患者多为青壮年,均发生于继发型肺结核,兼症多,合并糖尿病、慢性乙肝、慢性肺心病、银屑病、尘肺等,影像学表现为病灶范围较广,多为双肺,常伴有空洞和支气管狭窄;症状较重,体征明显,病程时间长;在药敏结果出来之前,含利福平的化疗过程中效果不佳,甚至于恶化。结论早期、规律、全程、联合、适量,再加合理的化疗方案,才能有效地预防、控制和治疗依赖利福平分枝杆菌的肺结核。

Objective To discuss the clinical feature of Rifampin Dependent Mycobacterium tuberculosis. Methods Binding with Clinical data, 112 cases of pulmonary tuberculosis by rifampin-depending strains classified by sputum culture and drug sensitivity of outpatients and inpatients from Jan 2001 to Dec 2008 were analyzed. Results Most of 26 patients were young adults and from secondary pulmonary tuberculosis, combined with vast symptoms,like diabetes, chronic hepatitis B, chronic cor pulmonale patients, psoriasis, pneumoconiosis etc. Imaging manifests extensive focus on both lungs, often went with cavum and bronchostenosis. Patients suffered grievous symptom, showd obvious physical signs and with long courses. Before drug sensitivity test, chemotherapy with rifampin had no effective result, or aggravated state of the illness. Conclusion Only earlier regular united congruent feasible chemotherapy scheme from end to end can prevent and cure rifampin-depending pulmonary tuberculosis.