小剂量环孢菌素A联合雄激素治疗再生障碍性贫血

Low-dose Cyclosporine A Combined Androgenin Treatment of Aplastic Anemia

目的探讨小剂量环孢菌素A联合雄激素治疗再生障碍性贫血的临床疗效。方法46例再生障碍性贫血的患者随机分为观察组和对照组,对照组用雄激素治疗,观察组在对照组治疗的基础上加用小剂量环孢菌素(CsA)3 mg/(kg.d),口服。疗程至少3个月,如无效停用,有效再继续服用3～6个月减量、停药并随访观察。结果两组患者经治疗后总有效率观察组为86.9%,对照组为65.2%,两组比较有统计学意义(P<0.05)。观察组治疗前后血象的变化经比较差异有统计学意义(P<0.05)。结论环孢菌素A联合雄激素治疗再生障碍性贫血是有效的治疗方案,其不但安全可靠,且不良反应少,值得临床推广应用。

Objective To explore clinical efficacy of the low - dose cyclosporine A combined androgen treatment of aplastic anemia. Methods Total 46 cases of aplastic anemia patients were randomly divided into observation group and control group, control group with androgen treatment, the observation group based on the control group treated with CsA 3 mg/ （ kg · d）, Oral. Treatment for at least 3 months, stop it if void , if effective continue to take 3 to 6 months reduction, discontinuation of treatment and follow - up observation. Results The two groups of patients have been treated and the overall efficiency of the observation group was 86. 9% ,65.2% for the control group, two groups has statistical significance （ P 〈 0. 05）. Group before and after treatment to observe changes in hemogram comparison there was a significant difference （ P 〈 0. 05 ）. Conclusion Cyclosporine A combined androgen in treatment of aplastic anemia are effective treatment programs, and its not only safe, reliable, and less adverse reactions, it is worth clinical application.