局部亚低温治疗对大面积脑梗死的临床意义

Clinical Significance of Local Mild Hypothermia Therapy on a Large Area of Cerebral Infarction

目的总结早期应用局部亚低温治疗大面积脑梗死的经验及临床意义。方法选择发病在6～24h的大面积脑梗死患者45例,随机分为亚低温治疗组23例,常规治疗组即对照组22例。两组患者均在入院时、第7d、第14d、第30d进行SSS神经功能缺失评分。结果两组SSS神经功能评分第14d、第30d治疗组有明显低于对照组(P<0.05)。治疗组总有效率(95.7%),明显高于对照组(68.2%)(P<0.05)。结论局部亚低温治疗可明显改善重症脑梗死的神经功能及预后,起到脑保护作用,且远期疗效更具有临床价值,无不良反应。

Objective To explore the clinical significance of early local mild hypothermia treatment on a large area of cerebral infarction. Methods Total 45 patients with large - area cerebral infarction（incidence within 6- 24h） were randomly separated into mild hypothermia treatment group 23 cases, the conventional treatment group or control group, 22 cases. At 1,7, 14,8,30 days, the effects were assessed by SSS neurological deficits score. Results By SSS neurological deficits score, the treatment group was significantly lower than that of the control group at 14,30 days （ P 〈0. 05）. The total effective rate in treatment group （95.7%） is significantly higher than that（68.2% ） of control group （ P 〈 0.05 ）. Conclusion Local mild hypothermia can significantly improve the treatment and prognosis of severe cerebral nerve function, play the role of cerebral protection, and long - term effect has more clinical value, but no adverse reactions.