摘要
目的探讨姜黄素对肿瘤血管形成抑制作用机制。方法通过建立动物肿瘤模型,运用分别实验治疗,结合免疫组化,检测其肿瘤内血管密度以及瘤体Ang-2和HIF-1α的表达。结果姜黄素中剂量和大剂量姜黄素组的S180瘤体内微血管密度均明显低于对照组;免疫组化显示中剂量和大剂量姜黄素组可抑制S180瘤体内Ang-2和HIF-1α的表达。结论姜黄素对小鼠S180肉瘤血管形成有明显抑制作用,降低Ang-2和HIF-1α的表达可能是其抑制肿瘤血管形成的主要机制之一。
Objective To investigate inhibitory effect of curcumin on angiogenesis of S180 sarcoma in mice. Methods The vascular density of S180 sarcoma were tested in animal tumor model with experimental treatment. The expression of Ang-2 and HIF-1α were measured by immunohistochemistry. Results When the middle and high dose was used,the vascular density of S180 sarcoma was lower than that of control group. And the expression of Ang-2 and HIF-1α was down-regulated when the middle and high dose were used. Conclusion Cureumin has inhibitory effect on S180 sarcoma and inhibitory effects on angiogenesis. Its mechanism may be assioeiated with the down-regulating of the expression of Ang-2 and HIF-1α.
出处
《中国实用医药》
2009年第15期60-61,共2页
China Practical Medicine
