摘要
目的:评价叶黄素作为食品添加剂和保健食品原料的食品安全性。方法:按照我国卫生部《食品安全毒理学评价程序和检验方法规范》,采用急性毒性实验、Ames实验、小鼠骨髓嗜多染红细胞微核实验、小鼠精子畸形实验进行检测。结果:大、小鼠急性经口LD50>10000mg/kg,Ames实验、小鼠骨髓嗜多染红细胞微核实验、小鼠精子畸形实验结果均为阴性。结论:叶黄素属于无毒物质,可以作为一种食品添加剂和保健食品原料进行开发、利用。
Objective: to evaluate the edible safety of lutein as food additive and health food material Methods: according to the technical standards for test and toxicological assessment of health food issued by Healthy Ministry of PRC,the acute toxicity LD50 test in mice,the test of micronucleus of polychromatic erythrocytphilic of young mouse, mouse sperm aberration test and Ames test were performed.Results: the oral LD50 in rats was greater than 10000mg/kg,three terms of hereditary toxicity were all negative.Conclusion:lutein was a kind actual no toxicity substances and may be develop as food additive and health food material.
出处
《食品工业科技》
CAS
CSCD
北大核心
2009年第5期296-298,共3页
Science and Technology of Food Industry