银杏叶片灌肠治疗对慢性功能肾衰竭大鼠模型肾功能影响的实验研究

Experimental Research of Effect of Ginkgo Enema on Renal Function of Failure Rat Model with Chronic Renal

目的:探讨银杏叶片灌肠治疗慢性肾衰竭大鼠的作用及护理措施的实施。方法:通过SPF级SD雄性大鼠48只,随机分为4组,建立慢性肾功能衰竭大鼠模型,并结合灌肠速度、时间、灌肠液的温度护理措施的应用,观察银杏叶片灌肠后模型大鼠体重变化,血尿素氮(BUN)、肌酐(Scr)、24h尿蛋白量、血液学及生化等肾功能的变化。结果:银杏叶片灌肠结合恰当的护理措施能显著降低血BUN、Scr及24h尿蛋白量,改善血液中电解质水平。结论:银杏叶片灌肠能够减轻大鼠慢性肾衰症状并延缓肾衰进程。结合恰当的护理措施,可为银杏叶片中药灌肠治疗慢性肾功能不全提供实验依据。

Objective：To explore the effect of renal function of ginkgo capsule on rats renal failure. Method： 48 rats divided into four group, Chronic renal failure of CRF rat models were administered with ginkgo capsule. The serum levels of blood urea nitrogen（BUN） and serum creatinine （ Scr）, hematological and biochemical indexes and renal histological features were observed. Result： Ginkgo capsule reduced levels of BUN and Scr amelioratedthe electrolyte, increased the number of red blood cell and hemoglobin content, and alleviated pathological changes of the kidney tissue. Conclusion： Ginkgo capsule can relieve the rat CRF symptoms and postpone the progress of CRF.