血管内皮生长因子与膜型基质金属蛋白酶-1在口腔鳞状细胞癌表达及意义

Expression of VEGF and MT1-MMP in Oral Squamous Cell Carcinoma and its Significance

[目的]检测血管内皮生长因子(VEGF)和膜型基质金属蛋白酶-1(MT1-MMP)在口腔鳞状细胞癌(OSCC)中的表达,并探讨其意义。[方法]采用免疫组织化学SP法检测VEGF、MT1-MMP在40例OSCC和10例口腔正常黏膜组织中的表达。[结果]VEGF和MT1-MMP在OSCC组织中的阳性表达率分别为67.50%和75.00%,在正常口腔黏膜组织中均阴性表达,差异有显著性(P<0.001)。VEGF表达与OSCC的临床分期(P<0.05)及淋巴结转移显著相关(P<0.01),与肿瘤的分化程度无关。MT1-MMP表达与OSCC的分化程度(P<0.05)及淋巴结转移显著相关(P<0.01),但与肿瘤的临床分期无相关性。VEGF与MT1-MMP表达呈正相关(rs=0.650,P<0.001)。[结论]VEGF与MT1-MMP在OSCC发生发展中起重要作用,共同促进OSCC的浸润转移。

[Purpose] To investigate the expression of vascular endothelial growth factor（VEGF） and membrane type 1 matrix metalloproteinase （MT1-MMP） in oral squamous cell carcinoma（OSCC） and its significance. [Methods] Immunohistochemical staining was used to detect the expression of VEGF and MT1-MMP in 40 cases with oral squamous cell carcinoma and 10 cases with oral normal mucosa. [Results] The positive rates of VEGF and MT1-MMP in OSCC were 67.50% and 75.00% respectively, while all negative in oral normal mueosa, the difference was significant （P〈0.001）. The expression of VEGF in OSCC was related to clinical stages （P〈0.05） and lymph node metastasis （P〈 0.01）, but not related to cancer differentiation. The expression of MT1-MMP in OSCC was related to the differentiation （P〈0.05） and lymph node metastasis （P〈0.01）, but not related to the clinical stages. There was a close positive correlation between VEGF and MT1-MMP （rs=0.650,P〈0.001）. [Conclusion] VEGF and MTI-MMP play an important role during carcinogenesis and development of OSCC. and thev accelerate the invasion and metastasis of OSCC.