子宫内膜异位症组织AIB1表达及其与ER和PR相关性

THE CORRELATION OF EXPRESSIONS BETWEEN NUCLEAR RECEPTOR COACTIVATOR AIB1 AND ESTROGEN AND PROGESTERONE RECEPTORS IN ENDOMETRIOSIS

目的探讨子宫内膜异位症(EM)病人异位内膜和在位内膜中核受体共激活因子(AIB1)蛋白的表达,以及其与雌激素受体(ER)、孕激素受体(PR)表达的关系。方法采用免疫组化法,分别检测45例EM病人的异位内膜和在位内膜以及42例正常子宫内膜(对照组)的AIB1、ER、PR蛋白的表达。结果异位内膜和在位内膜AIB1的表达均显著高于对照组(t=15.897、14.430,P<0.01);异位内膜中ER、PR的表达显著低于对照组(t′=4.482、2.937,P<0.05);异位内膜中AIB1与ER呈负相关(r=-0.712,P<0.01)。结论AIB1、ER和PR在子宫内膜中的异常表达可能与EM的发生发展有关。

Objective To study the expression of AIB1 in eutopic and ectopic endometrium in patients with endometriosis （EM）, and its association with the expressions of ER and PR. Methods The expressions of AIB1, ER and PR, in both eutopic and ectopic endometrium of 45 EM patients, as well as in 42 normal control endometrium were detected immunohistochemically. Results The expressions of AIB1 in eutopie and ectopic endometrium in EM patients were significantly higher than that of the control group （t= 15. 897,14. 430;P〈0.01）. ER and PR expressions in ectopic endometrium were lower than that of the control （t′= 4. 482,2. 937 ;P〈0.05）. AIB1 expression in ectopic endometrium was negatively related to ER （r= -0. 712,P〈0.01）. Conclusion The abnormal expressions of AIB1, ER and PR in endometrium may be correlated with the pathogenesis and development of EM.