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胃癌Egr-1基因表达水平与临床病理的关系 被引量：2

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摘要 目的研究胃癌组织中Egr-1基因表达水平与临床病理的关系。方法采用RT-PCR法检测胃癌、正常切缘胃组织中Egr-1 mRNA的表达水平。免疫组化法检测胃癌组织、正常切缘胃组织中Egr-1 mRNA相应蛋白表达水平。病理检查确定胃癌组织病理类型、分化程度及淋巴结转移情况。结果胃癌组织中Egr-1 mRNA及Egr-1蛋白表达水平明高于正常胃组织(P<0.01);低分化胃癌中表达水平高于高分化胃癌(P<0.01);有淋巴结转移组表达水平高于无淋巴结转移组(P<0.01)。结论Egr-1基因表达与胃癌发生发展及转移发生机制密切相关,对胃癌预后判定有重要意义。
作者 高峰 张中平 陈育建
机构地区 江苏大学附属武进医院消化内科
出处 《广东医学》 CAS CSCD 北大核心 2009年第6期940-942,共3页 Guangdong Medical Journal
基金 江苏省常州市武进科委立项资助(编号:WS2007009)
关键词 胃肿瘤 早期生长反应基因 EGR-1
分类号 R378.61 [医药卫生—病原生物学] R735.2 [医药卫生—肿瘤]
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参考文献9

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共引文献3

同被引文献22

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二级引证文献11

广东医学
2009年 第6期

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