摘要
目的探讨血脂康对高胆固醇饮食家兔血管内皮细胞功能的保护作用。方法健康纯种新西兰白兔30只,随机分层分组法分为对照组(普通饲料),高脂组(普通饲料+15%胆固醇),治疗组(普通饲料+15%胆固醇+血脂康08g·kg-1·d-1),在实验不同阶段,观察各组家兔血清脂质、一氧化氮及血浆内皮素、前列环素、血栓素含量及血管内皮细胞病理形态学改变。结果实验前各组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、血浆内皮素(ET)1、血清一氧化氮(NO)、血浆血栓素(TX)B2及6酮前列腺素(PG)F1α等无明显差异。实验12周,高脂组、血脂康治疗组血清TC、TG、LDLC及血浆ET1、TXB2及TXB2/6酮PGF1α比值明显高于对照组,但治疗组明显低于高脂组(P值均<0.05);血浆NO低于对照组(P<0.05),但治疗组高于高脂组(P<0.05)。病理结果显示:血脂康治疗组主动脉、冠状动脉粥样硬化病变及血管内皮细胞损伤明显轻于高脂组。结论血脂康具有明显的调整脂质代谢及保护血管内皮细胞功能的作用。
Objective Xuezhikang is refined from Chinese traditional medicine Hongqu, its main component is HMGCoA reductase inhibitor. The protective effects of Xuezhikang (0.8 g·kg-1·d-1) on the functions of endothelial cell (EC) during the progression of atherosclerosis were investigated in rabbits fed with 1.5% cholesterol diet in this study. Methods 30 New Zealand white rabbits were divided into 3 groups (control group, hypercholesterol group and Xuezhikang group) during the 12week experiment. Serum lipids, nitrous oxide (NO) and plasma endothelin (ET)1, thromboxane (TX)B2, 6ketoprostaglandin (PG) F1α concentrations and histopathological changes of ECs were followed. Results Serum total cholesterol, lowdensity lipoprotein cholesterol, triglyceride, plasma ET1 concentrations and the ratio of TXB2/6ketoPGF1α in plasma decreased and serum NO level increased in Xuezhikang group as compared with those of hypercholesterol group (P<0.05). The area of lipid deposition on the intimal surface of the aorta and coronary arteries was reduced and the ultrastructural injuries of ECs were milder in Xuezhikang group. Conclusion Xuezhikang had antiatherogenic properties and the protection of functions of vascular ECs might be involved in the mechanisms of Xuezhikang against atherosclerosis.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1998年第6期367-370,共4页
Chinese Journal of Internal Medicine
关键词
血管内皮
动脉粥样硬化
血脂康
Endothelium, vascular Atherosclerosis Xuezhikang