阿尔茨海默病和血管性痴呆患者血脂水平的研究

Study of blood-fat in patients with alzheimer disease or vascular dementia

目的探讨阿尔茨海默病(AD)和血管性痴呆(VaD)与血脂的关系。方法测定23例AD患者(AD组)、20例VaD患者(VaD组)及30例健康人(对照组)的血脂水平,并进行比较。结果AD组中血浆总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)明显高于对照组(P<0.05),2组间三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平比较无显著性差异(P均>0.05);VaD组中TC、TG明显高于对照组(P均<0.05),VaD组HDL-C、LDL-C及AD组HDL-C水平明显高于VaD组(P均<0.05),2组间TC、TG、LDL-C水平比较无显著性差异(P均>0.05)。结论患者血胆固醇增高可能与AD、VaD的发病有关,降低血脂可能有助于AD和VaD的防治。

Objective It is to approach the relationship between the blood-fat and alzheimer disease （AD） or vascular dementia （VaD）. Methods The levels of blood-fat of 23 patients with AD （AD group）, 20 VaD （VaD group） and 30 normal controls （control gruop） were respectively measured and compared. Results The levels of TC and HDL- C in AD group were higher than that of control group （P （0.05）, but there was no difference in the levels of TG, LDL- C with the two groups （P〉0.05） ; The levels of TC and TG in VaD group were higher than that of controls group（P〈0.05）, but there was no difference in levels of HDL - C, LDL - C with the two groups; The level of HDL - C in AD group was higher than that of VaD group （P（0.05）, there was no difference in levels of TC, TG, LDL-C between the two groups. Conclusion Patients with higher levels of blood-fat may has higher risk of AD and VaD than the normals, and decreased cholesterol levels may be beneficial for preventing and treating for AD and VaD.