活性氧诱导运动中肌源性IL-6产生的信号转导通路述评

Review of signal transduction channels for active oxygen to induce the production of interleukin-6 originating from muscles during exercising

就运动中活性氧诱导肌原性IL-6产生的机制等问题做综述。IL-6是运动过程中变化非常明显的一种细胞因子,其变化幅度与运动时间和运动强度关系密切。研究表明,运动中生成的IL-6主要来源于收缩的骨骼肌,骨骼肌在运动过程中产生的自由基,尤其是活性氧是运动中诱导IL-6产生的一个主要原因。

The authors gave an overview of such issues as the mechanism for active oxygen to induce the production of interleukin-6 （IL-6） originating from muscles during exercising. IL-6 is a type of cytokine that changes very significantly in the process of exercising; its changing magnitude is closely related to exercise time and exercise intensity. Via their study the authors revealed the following findings： IL-6 produced during exercising originates primarily from contracting skeletal muscle; free radicals produced by skeletal muscle in the process of exercising, especially active oxygen, are a major cause for inducing the production of IL-6 during exercising.