肺癌患者介入治疗前后凝血、纤溶及血小板功能的变化

Alternation of Blood Coagulation,Fibrinolytic and Platelet Function Before and After the Interventional Therapy of Primary Pulmonary Carcinoma

目的研究原发性支气管肺癌介入治疗前(A1组)、后(A2组)凝血及纤溶功能的变化。方法比较A1组(52例)、A2组(52例)及30例对照组(B组)指标。PT、aPTT、TT、Fbg、FⅦ、FⅧ、FⅩ采用光散射比浊法,P-选择素(Ps),血管性血友病因子(vWF),尿激酶型纤溶酶原激活物(uPA)采用ELISA法,uPA抑制物(PAI)采用发色底物法测定。结果1.与B组比较,A1组aPTT、TT、Fbg、FⅧ、Ps、vWF、uPA和PAI均升高(P<0.05～0.01)。2.与A1组比较,A2组Fbg、FⅧ、Ps、uPA和PAI降低(P<0.05～0.01)。结论原发性支气管肺癌患者凝血及纤溶过度激活,血小板活化,介入治疗后减轻。

Objective To terventional therapy of primary study the changes of blood coagulation and fibrinolytic function before the inpulmonary carcinama （group A1 ） and after that （ group A2） . Methods To analyze PT, aPTT, TF, Fbg, F Ⅶ, F Ⅷ, F X in group A1 （ n = 52 ）, group A2 （ n = 52 ） and control group （group B n = 30） with the light scattering turbidimetry, and P-selectin （Ps）, you Willebrand factor （vWF）, urokinase profibrinolytic activating factor （uPA） were examined by ELISA, and uPA＇ s inhibitor （PAl） with chromogenic substracte. Results aPTT , TT,Fbg,FⅧ,Ps,vWF,uPA and PAl in group A1 were higher than those in group B（P 〈0.05 -0.01 ）. Fg,FⅧ,Ps,uPA and PAI in group A2 were less than those in group A1 （ P 〈 0.05 - 0.01 ）. Conclusion The blood coagulation and fibrinolytic function of primary pulmonary carcinoma were over activated, platelet was animated, and abated after interventional therapy