异丙酚对大鼠心肌收缩力的影响

The effects of propofol on myocardial contractility in rat vivo

目的:判定异丙酚对大鼠心脏心肌收缩力的影响及其程度。方法:20只大鼠随机分为两组,Ⅰ组静注异丙酚2.5mg·kg^(-1),Ⅱ组静注硫喷妥钠4mg·kg^(-1),测量注药后30秒、1、2、5、10分钟时dp/dt_(max)、LVSP和LVDP、CVP、HR的变化。结果:静注异丙酚后dp/dt_(max)无显著变化(P>0.05),而静注硫喷妥钠后1分钟dp/dt_(max)明显下降(P<0.05)。注药后两组LVSP和LVDP均明显下降(P<0.05),CVP明显升高(P<0.05),HR无明显变化(P>0.05)。结论:异丙酚对心肌收缩力影响较小,与等效剂量的硫喷妥钠相比,心肌抑制作用不明显。

To determine the effect of propofol on myocardial contractility. Method: Twenty hamsters were allocated to receiving intravenous propofol 2.5mg·kg^(-1)(group Ⅰ) or thiopentone 4mg·kg^(-1)as control (group Ⅱ) dp/dt_(max), was determined using a catheter inserted into the left ventricle from right carotid artery. LVP (LVSP, LVDP, LVMP), CVP, HR were recorded simutaneously. Resutt: dp/dt_(max), decreased insignitieantly in group Ⅰ but signitieantly in group Ⅱ. LVP(LVSP, LVDP, LVMP) decreased, while CVP increased significantly in both groups (P<0.05). The changes of HR were not statistically significant in both groups (P>0.05). Conclusion.. The influence of propofol on myocardial contractility is weaker than that of thiopenone.