艾司洛尔预防气管插管血液动力学的改变

Effects of esmolol on hemodynamics during tracheal intubation

目的:评价国产盐酸艾司洛尔(简称E)预防气管插管血液动力学改变的临床效果。方法:100例择期手术病人随机分成3组,A组E1.0mg/kg,B组E2.0mg/kg,C组(对照组)生理盐水10ml。观察给药前、插管前、插管后1、2、3、5、10分钟三组SP、DP、HR、RPP变化。结果:A、B两组用E后HR减慢,尤其插管后3分钟和10分钟与C组比较有显著差异(P<0.05);C组插管后SP在1和3分钟增高极显著(P<0.01),至10分钟仍高于插管前及A、B两组(P<0.05),而A与B组之间SP无统计学差异;A、B两组RPP值始终小于12 000;C组插管后1、2分钟超过12 000(P<0.01),至10分钟仍高于A、B两组(P<0.05)。结论:艾司洛尔可减轻气管插管引起的血液动力学改变。

To evaluate the effects of esmolol hydroehloride on hemodynamies during tracheal intubation. Method: One hundred patients undergoing elective cerebral, thoracic or abdominal operations, were randomly divided into three groups: Group A, Group B and Group C, which were injected I. V. esmolol 1.0mg/kg, 2.0mg/kg and normal saline 10ml respectively before induction of anesthesia. SP, DP, HR and RPP were recorded immediately before administration, before intubation and 1,2,3,5 and 10 min after intubation. Result: HR in Group A and Group B was signifcantly slower than in Group C, especially 3 min and 10 min after intubation(P<0.05). SP in Group C increased 1 and 3 min after intubation(P<0.01 ) and was still higher 10 min after intubation than before intubation and in Group A and Group B (P<0.05). There were no differences in SP between Group A and Group B. RPP in Group A and Group 13 were less than 12 000 during whole procedures; RPP in Group C were beyond 12 000 1 and 2 rain after intubation and still higher than in Group A or Group B 10 min after intubation(P<0.05). Conclusion: Esmolol may attenuate the hemodynamic changes induced by tracheal intubation.