5α-还原酶特异抑制剂非那甾胺的合成

Synthesis of 5α-Reductase Special inhibitor Finasteride

以3β-羟基孕甾-5-烯-20-酮-3-醋酸酯为起始原料,经溴仿、酯化、氧化、还原、胺化等反应,得中间产物N-叔丁基-3-羰基-4-氮杂-5-雄甾-17β-甲酰胺,再经碘代反应和脱碘反应脱去1、2位氢合成非那甾胺。

The Intermediate, N - tert - butyl - 3 - oxo - 4 - aza - 5 - androst - 17β - Formamide is synthe- sized from 3β - Hydroxypregn - 5 - en - 20 - one by bromoform reaction, esterification reaction oxidation reaction, reduction reaction, and amination reaction. Then Finasteride is prepared by dehydrogenation of 1,2 - position with iodination and iodine removal.