纳洛酮联合氨茶碱治疗Ⅱ型呼吸衰竭肺性脑病的临床观察

Observation of the clinical effect of naloxone combined with aminophylline on type Ⅱ respiratory failure with pulmonary encephalopathy

目的观察纳洛酮联合氨茶碱治疗Ⅱ型呼吸衰竭肺性脑病临床疗效。方法将入选80例患者随机分为治疗组及对照组,各40例。2组均予以积极的综合治疗。治疗组在此基础上加用纳洛酮联用氨茶碱治疗,比较2组的治疗效果。观察2组治疗前后动脉血气分析(PaO2、PaCO2)的变化情况。结果治疗组有效率为90.0%,高于对照组的70.0%,差异有统计学意义(P<0.05)。治疗后2组PaO2、PaCO2值均较治疗前有所改善(P<0.01),且治疗组在治疗后情况改善程度优于对照组(P<0.05)。结论纳洛酮联用氨茶碱治疗Ⅱ型呼吸衰竭肺性脑病临床疗效确切、安全。

Objective To observe the clinical effect of naloxone combined with aminophylline on type Ⅱ respiratory failure with pulmonary encephalopathy. Methods 80 cases were randomly divided into treatment group and control group, and two groups were treated with comprehensive treatment. On the basis of the treatment group ,40 cases were added aminophylline combined with naloxone in treatment group. Then comparison of two groups were made. Results The total efficiency of the treatment group was higher than that of control group（90.0% vs 70.05% ,P 〈0.05 ）. The level of PaO2 ,PaCO2 in the treatment group were improved after treatment （ P 〈 0.01 ）, and there was significant difference between two groups （ P 〈 0.05 ）. Conclusion Naloxone combined with aminophylline is safe and effective in the treatment of type Ⅱ respiratory failure with pulmonary encephalopathy.