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皮下脂膜炎样T细胞淋巴瘤中P27及Cyclin D3的表达及其意义

Expression and Significance of P27 and Cyclin D3 in Subcutaneous Panniculitis-Like T-Cell Lymphoma
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摘要 目的:探讨皮下脂膜炎样T细胞淋巴瘤(SPTL)中P27及Cyclin D3的表达和意义。方法:应用免疫组化检测20例SPTL标本中P27及Cyclin D3的表达。结果:P27及Cyclin D3在SPTL均出现较高表达,且P27蛋白与肿瘤细胞浸润血管有关(P<0.05);P27与Cyclin D3蛋白表达之间无相关性(P>0.05)。结论:P27及Cyclin D3在SPTL发生发展中起着一定作用。 Objective： To investigate the expression and significance of P27 and Cyelin D3 in subcutaneous panniculitis-iike T-ceU lymphoma （SPTL）. Methods： Immunohistochemical Elivision was used to observe the expression of P27 and Cyclin D3 in 20 cases of SPTL. Results： P27 and Cyelin D3 were highly expressed in SPTL, and the expression of P27 was related to the vascular infiltration by tumor celis（P〈0.05） ;there was no correlation between the two biomarkers （P〉0.05 ）. Conclusion： The expression of P27 and Cyclin 133 plays an important role in the pathogenesis and development of SPTL.
作者 杨翰君 徐晨 邹宇 万川 王琳 阚蓓 李俸媛 廖殿英 刘卫平 李甘地
机构地区 四川大学华西医院皮肤性病科 重庆市第九人民医院 成都铁路局成都铁路中心医院 江西省皮肤病专科医院 成都市第二人民医院 四川大学华西医院病理科
出处 《华西医学》 CAS 2009年第5期1115-1119,共5页 West China Medical Journal
基金 2005年四川大学华西医院留学回国人员科研启动基金资助项目(136050122)
关键词 淋巴瘤 T细胞 皮肤肿瘤 脂膜炎 P27 CYCLIN D3 lymphoma T-cell cutaneous tumor panniculitis P27 cyclin D3
分类号 R739.5 [医药卫生—肿瘤]
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参考文献22

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二级参考文献17

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华西医学
2009年 第5期

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