雄激素受体与P21活化激酶在前列腺癌发生中的作用
摘要
前列腺癌为老年病,是欧美国家最常见的肿瘤,随着人类平均寿命的延长和诊断技术的提高嘞列腺癌在世界癌症总发病数中占十分之一,伞球范围内每年约有20万患者死于前列腺癌。在美国,前列腺癌已经跃居第2位致死癌,约半数年龄大于50岁男性前列腺中可发现癌细胞。前列腺癌的发病原因迄今仍不清楚,目前认为激素、人种、遗传和饮食习惯等与发病都有比较密切的关系,其中雄激素在前列腺(癌)的生长、转移与分化中起决定性作用,由雄激素依赖性转变为雄激素非依赖性是每个致死性前列腺癌细胞的根本特性。
出处
《农垦医学》
2009年第2期163-165,共3页
Journal of Nongken Medicine
参考文献21
-
1Floey R,Hollywood D,Lawler M.Molecular pathology of prostate caner:the key to identifying new biomarkersof disease[J].Endocrine-Related Cancer,2004,11:477.
-
2Denmeade S R and Isaacs J T.A history of prostate cancertreatment[J].Nature Reviews Cancer,2002,2:389-396.
-
3Jemal A,Siegel R,Ward E,et al.Cancer statistics[J].CA:A Cancer Journal for Clinicians,2006,56:106-130.
-
4Debes J D,Tindall D J.Mechanisms of androgen-refractory prostate cancer[J].N Engl J Med,2004,351:15.
-
5Grossmann M E,Huang H,Tindall D J.Androgen receptor signaling in androgen-refractory prostate cancer[J].J Nat Cancer Institute,2001,93(22):1687.
-
6Craig J Burd,Lisa M Morey and Karen E Knudsen.Androgen receptor corepressors and prostate cancer[J].Endocrine-Related Cancer,2006,13:979-994.
-
7McEwan I J.Molecular mechanisms of androgen receptor-mediated gene regulation:structure-function analysis of the AF-1 domain[J].Endocrine-Related Cancer,2004,11:281.
-
8Yousef G M,Diamandis E P.Expanded human tissue kallikrein family-a novel panel of cancer biomarkers[J].Tumour Biol,2002,23(3):185-92.
-
9Sartor O,Zheng Q,Eastham J A.Androgen receptor gene CAG repeat length varies in a race specific fashion in men without prostate cancer[J].Urology,1999,53:378-380.
-
10Bokoch G M.Biology of the p21-activated kinases[J].Annu Rev Biochem,2003,72:743-81.
二级参考文献11
-
1Edwards J, Bartlett JM. The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1 : Modifications to the androgen receptor. BJU Int,2005,95:1320-1326.
-
2Culig Z,Comuzzi B, Steiner H, et al. Expression and function of androgen receptor coactivators in prostate cancer. J Steroid Biochem Mol Biol,2004 ,92 :265-271.
-
3Cai G, Huang H, Shapiro E, et al. Expression of androgen receptor associated protein 55 ( ARA55 ) in the developing human fetal prostate. J Urol,2005 ,173 :2190-2193.
-
4Lee SR,Ramos SM,Ko A,et al. AR and ER interaction with a p21-activated kinase ( PAK6 ). Mol Endocrinol,2002,16:85-99.
-
5Yang F, Li X,Sharma M, et al. Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6. J Biol Chem, 2001,276 : 15345-15353.
-
6Schrantz N ,Correia JS, Fowler B, et al. Mechanism of p21-activated Kinase 6-mediated Inhibition of Androgen Receptor Signaling. J Biol Chem, 2004,279 : 1922-1931.
-
7Barrios-Rodiles M, Brown KR, Ozdamar B, et al. High-throughput mapping of a dynamic signaling network in mammalian cells. Science, 2005,307 : 1621-1625.
-
8Sanders LC, Matsumura F, Bokoch GM, et al. Inhibition of myosin light chain kinase by p21-activated kinase. Science, 1999,283:2083-2085.
-
9Gururaj AE,Rayala SK, Kumar R. p21-activated kinase signaling in breast cancer. Breast Cancer Res,2005 ,7 :5-12.
-
10Callow MG, Clairvoyant F,Zhu S, et al. Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines. J Biol Chem, 2002,277 : 550 -558.
共引文献3
-
1刘彤,李洋,朱戈,李丰.不同激酶活性的hPAK6基因原核表达载体的构建及重组蛋白的表达[J].中国医科大学学报,2011,40(12):1057-1059.
-
2蔡松旺,李小娟,陈锐涵,朱宝益,蔡燚,叶春伟,陶奕然,冯淑君,温星桥.微小RNA-23a-p21活化激酶6通路对前列腺癌细胞迁移与侵袭能力的影响[J].中华实验外科杂志,2012,29(7):1360-1362. 被引量:8
-
3蔡松旺,黄怀球,李小娟,陈锐涵,蔡燚,朱宝益,陶奕然,叶春伟,温星桥.微小RNA-23a调节前列腺癌细胞骨架蛋白的分子机制[J].中华实验外科杂志,2012,29(8):1572-1573. 被引量:3
-
1郭山伟,孙苗苗,南芳芳.老年妇女卵巢肿瘤的研究现状[J].中国妇幼保健,2016,31(15):3196-3198. 被引量:2
-
2于文胜,石学涛,衣龙海,李胜,周武元.老年人原发性肝癌112例手术治疗分析[J].肿瘤防治杂志,2004,11(10):1117-1118. 被引量:2
-
3刘彦中,韩文周,侯良宝.978例老年食管癌的手术治疗分析[J].临床肿瘤学杂志,2008,13(3):258-259. 被引量:9
-
4顾方六.有关前列腺癌的几个问题[J].老年医学与保健,1999,5(4):151-153. 被引量:1
-
5陈锐深.中医药治疗恶性肿瘤的特色和优势[J].华夏医药,2005,9(2):100-103.
-
6曾子奕,徐海帆.DNA甲基化与肿瘤的相关研究[J].现代医药卫生,2015,31(7):1007-1009. 被引量:4
-
7王新敏,章乐,王勤章,丁国富.前列腺癌与前列腺增生组织中P21活化激酶6的表达及意义[J].中国老年学杂志,2011,31(16):3013-3015. 被引量:3
-
8陈国华.105例老年人胃癌治疗分析[J].浙江临床医学,2008,10(5):675-676. 被引量:3
-
9马富贵.11例老年人胃癌治疗分析[J].中国伤残医学,2013,21(9):241-241.
-
10邵廷彬.恶性肿瘤“忌”刺激[J].中国药业,1996,5(1):43-43.